501 Main Street
Dubuque, IA 52001

Now Preleasing! NEW DOWNTOWN DUBUQUE RETAIL & RESTAURANT OPPORTUNITY! Be among the first commercial tenants in a signature new five-story mixed-use development currently under construction and anticipated for Fall 2027. This 9,132 SF street-level commercial space offers prominent Main Street frontage, exceptional visibility, 12-foot-tall storefront windows, and opportunities for impactful signage and branding. Designed with flexibility in mind, the space is ideally suited for high-end retail, boutique concepts, café, or quality food and beverage users, with build-to-suit options available. The property will feature 102 luxury apartment units...read more on-site, creating a built-in customer base alongside daily traffic from downtown residents, employees, visitors, students, and year-round events. Located in the heart of Downtown Dubuque and directly adjacent to the future John & Alice Butler School of Osteopathic Medicine, opening in 2028, the development is positioned at the center of significant downtown growth. The location is also steps from the Dubuque Museum of Art expansion, Town Clock Plaza, Northeast Iowa Community College, and Five Flags Center, with Washington Park, Cathedral Square, the Port of Dubuque, Millwork District, and Mississippi River waterfront all within walking distance. With a 92 Walk Score® and 71 Bike Score®, excellent highway access, and a prime position within the tri-state market, this is a rare opportunity to establish a premium retail or dining concept in one of Iowas most distinctive and evolving downtown districts.